Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

Please check our bioRxiv preprit for more information.

Y.T. developed the DeGAs web application. M.A.R supervised computational aspects of the study.

Decomposition - Methods overview

Video Tutorial for DeGAs App

Yosuke explains the DeGAs app and teaches viewers how to interpret scores and plots using examples. The coding variants is used as an example.

Available datasets

The following datasets are available now:

Naming convention

The name of the datasets corresponds to the following conditions:

  • all, coding, non-coding, and PTVs: This indicates the type of variants included in the analysis. PTVs = Protein Truncating Variants, coding = coding variants, non-coding = non-coding variants (does NOT include coding variants), and all = coding + non-coding.
  • nonMHC: By default, all the variants on autosomes are included in the analysis. nonMHC dataset has variants outside of major histocompatibility complex region.
  • z: The elements of summary statistic matrix is Z-score
  • non-center: By default, the left/right-singular vector from truncated-singular value decomposition is centered around zero. non-center datasets skip this procedure.
  • p[some value]: The default p-value threshold is 0.001. If there is a suffix like 'p0.01', that means the p-value threshold is adjusted to the specified value.